Ethnomedicinal, ecological, phytochemical, nutritional and pharmacological aspects of Sanguisorba officinalis L. (Rosaceae): A comprehensive review

Alexandra C. TOCAI (MOȚOC); Raluca A. CORB ARON; Diana UIVAROSAN; Antonia M. LESTYÁN; Andrea BADALE; Andrei G. TEODORESCU; Simona I. VICAS

doi:10.15835/nbha53414637

Authors

Alexandra C. TOCAI (MOȚOC) University of Oradea, Faculty of Medicine and Pharmacy, Department of Preclinical Disciplines, Piaţa 1 Decembrie 10, Oradea, 410073 (RO) https://orcid.org/0000-0002-8340-0004
Raluca A. CORB ARON University of Oradea, Faculty of Medicine and Pharmacy, Department of Preclinical Disciplines, Piaţa 1 Decembrie 10, Oradea, 410073 (RO) https://orcid.org/0000-0002-4425-215X
Diana UIVAROSAN University of Oradea, Faculty of Medicine and Pharmacy, Department of Preclinical Disciplines, Piaţa 1 Decembrie 10, Oradea, 410073 (RO) https://orcid.org/0000-0002-7568-5222
Antonia M. LESTYÁN 1) University of Oradea, Faculty of Medicine and Pharmacy, Department of Preclinical Disciplines, Piaţa 1 Decembrie 10, Oradea, 410073; 2) University of Oradea, Doctoral School of Biomedical Science, Oradea, 410073 (RO) https://orcid.org/0009-0006-6670-1215
Andrea BADALE University of Oradea, Faculty of Medicine and Pharmacy, Department of Preclinical Disciplines, Piaţa 1 Decembrie 10, Oradea, 410073 (RO) https://orcid.org/0000-0003-1071-5918
Andrei G. TEODORESCU University of Oradea, Faculty of Medicine and Pharmacy, Department of Morphological Disciplines, Piaţa 1 Decembrie 10, Oradea, 410073 (RO) https://orcid.org/0000-0002-0357-7652
Simona I. VICAS 1) University of Oradea, Doctoral School of Biomedical Science, Oradea, 410073 2) University of Oradea, Faculty of Environmental Protection, Department of Food Engineering, General Magheru 26, Oradea, 410048 (RO) https://orcid.org/0000-0001-9562-4809

DOI:

https://doi.org/10.15835/nbha53414637

Keywords:

antioxidant capacity, ethnobotany, flavonoids, interspecific relationships, phytochemistry, Sanguisorba officinalis L., tannins

Abstract

The medicinal properties of Sanguisorba species have been known since the 16^th century and have been used in traditional folk medicine ever since. The genus Sanguisorba includes approximately 148 species and subspecies and belonging to Rosaceae family distributed mainly in East Asia and southern Europe. The most widespread species in the genus Sanguisorba is Sanguisorba officinalis L. Currently available S. officinalis L. reports in the literature were mostly found on Google Scholar, Pubmed, Web of Science, Lens.org and Scopus. This review provides a detailed and focused analysis of S. officinalis L., deliberately centering on its unique properties and existing literature, without drawing comparative analysis with other species within the Sanguisorba genus. This article focuses on the taxonomy, habitat, distribution, ethno-medicinal uses, botanical characterization, nutritional composition, chemical composition, pharmacological effects, insect interactions, and conservation status of S. officinalis. Moreover, the present work attempts to compile various phytochemical and bioactivity investigations conducted on S. officinalis; the resulting data consistently highlight its therapeutic prospects, as evidenced by the wide range of secondary metabolites and biological activities reported. Despite its promising potential, limited clinical data and standardization issues present challenges for its integration into modern medicine. The mechanisms of action, safety profile, and therapeutic efficacy of S. officinalis warrant further investigation.

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